This 16 minute video tells the story of one of this century's most extraordinary scientific discoveries - induced pluripotent stem cells, or iPS cells. Medical doctor and scientist Shinya Yamanaka describes his Nobel prize-winning work. Together with other leading stem cell researchers, he talks about the scientific, medical and ethical implications of his reprogramming experiments. Cameron Duguid's distinctive animations take us inside the reprogrammed cell, and bring the science to life on screen.
Find out about the next revolution in medicine and how it can change your life.
Tune in to find out about the next revolution in medicine and how it can change your life. Featuring Curt Civin, Director of the Center for Stem Cell Biology and Regenerative Medicine. Assistant Dean for Research University of Maryland School of Medicine.
There is considerable excitement about the use of stem cells for cardiovascular disease. Stem cells are unspecialized cells with the unique property to self-renew or make copies of themselves and to differentiate into specialized cells. The goal of stem cell therapy is to enhance the body's natural process of regeneration. There are a considerable number of stem cells currently under investigation for patients with heart attacks, angina, heart failure, and peripheral arterial disease. We have made considerable progress but have many questions left to answer.
Timothy Henry, MD, FACC, is Chief of Cardiology at Cedars Sinai Heart Institute in Los Angeles, California. Dr. Henry earned his bachelor's degree at the University of North Dakota, graduated from medical school at University of California, San Francisco, in 1982, and was chief medicine resident from 1982--1986 at University of Colorado Health Sciences Center. He completed his training as a cardiology fellow, chief cardiology fellow, and interventional cardiology fellow at University of Minnesota in 1991. His research interests include interventional cardiology, acute myocardial infarction and novel therapies, including stem cell and gene therapy, for patients who are not candidates for standard revascularization techniques.
Science is working on it.
Aging is as much about the physical processes of repair and regeneration — and their slow-motion failure — as it is the passage of time. And scientists studying stem cell and regenerative biology are making progress understanding those processes, developing treatments for the many diseases whose risks increase as we get older, while at times seeming to draw close to a broader anti-aging breakthrough.
A white paper for CelBank owners
When Wayne and Vin first founded Next Healthcare in 2009, the company was at the forefront of the emerging field of regenerative cellular therapeutics. Over the next 5 years, this meant mainly the use of stem cells and other healing cells as they exist in the body in their natural state.
This work has come into the clinic and is now widely used in orthopedics, cosmetic surgery, heart disease and other fields.
In the meantime, medical leaders in molecular biology have learned how use genetic tools to activate the immune system to fight a person’s specific cancer. This field is referred to a cellular immunotherapy.
Many of you have asked me in the past if stem cells can cure cancer. Except as part of blood cancer therapy, they cannot. But CAR T-cells can. You have T-cells in your CelBank. We thought you should know more about this work.
The Immune System
If you have attended any of my seminars, you have heard my talk about the immune system. This is one of the better understood of the body’s cellular-based systems.
The main actors in the immune system are white blood cells, so called because they do not contain hemoglobin, the molecule that makes red cells red. The white cells come in dozens of types with all sorts of functions in body maintenance. Some remove bacteria, some our own deceased or damaged cells and tissues.
Several types have the special property of learning to recognize disease-causing viruses or bacteria. Collectively they are called the adaptive immune system. (1)
When you receive a vaccination, you are being exposed to a very weak disease causing agent that causes your adaptive immune system to learn to destroy these agents whenever they appear. This is why you can avoid becoming sick with the flu before ever being exposed to a new virus strain. Your body received a “warning” and could defeat the virus before it made you sick. Pretty cool, right?
Well, it gets better. Cancer cells, which are your own cells gone bad, aren’t detected as invading disease agents because they are your own cells. So, adaptive immunity doesn’t happen, normally, in cancer.
But cancer cells ARE different than normal cells. These differences can be taught to a special class of white cells called T-cells. And when they are taught, these T-cells will destroy all the cancer cells of that type in your body.
A New Tool to Treat Cancer
Through a process called adoptive cell transfer (2), cells called Chimeric Antigen Receptor (CAR) T-cells are created (3). The CAR T-cell now has the property of being able to recognize your cancer cells through certain chemical markers found on the surface of the cell. The CAR T-cells are created in a cell processing lab and then returned to the patient for the therapy.
A New Opportunity for CelBank Owners
At this point, the proceed has been proved effective in very difficult cancers in small human clinical studies. It will likely be about 4 years before large scale human studies are undertaken. Then another 4-5 for FDA approval (this is a biological drug.)
But remember the premise of CelBank. Younger cells process better. So if you get cancer in 15 years, you can use your younger cells for a better CAR T-cell outcome.
While you didn’t know this option would exist at the time of your bank, your faith in advances in the field of cellular therapy continues to look like a good decision.
By Dennis O’Brien, President, Next Healthcare Inc.
For More Information
Scientific summary of human clinical work with CAR T-cells (professional material)
Survey on human T-cell clinical work with solid tumor (professional material)
Sitting on the front steps of her Cockeysville, Md., home a year and a half ago, Vanna Belton was startled and thrilled when her eyes focused on a car’s license plate. Essentially blind for more than five years, she suddenly could read the numbers and letters.
“When I realized I could see the license plates, we started walking around the neighborhood reading them,” said Belton, recalling the excitement she and her fiancee felt at that moment. “We drove around and read store signs. The Pennsylvania Dutch Market. The tanning salon.”
Only 2 years after getting a stem cell transplant, half of volunteers showed improvement in their disability scores — a first for any MS therapy.
Dr. Richard K. Burt performed the first hematopoietic stem cell transplant (HSCT) for a multiple sclerosis (MS) patient in the United States at Chicago’s Northwestern Memorial Hospital. Now Burt, Chief of the Division of Medicine-Immunotherapy and Autoimmune Diseases at Northwestern University’s Feinberg School of Medicine, is making headlines again.
Experimental "trick" lets researchers compare embryonic stem cells and induced pluripotent stem cells in new way
Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital and Harvard Medical School have found new evidence suggesting some human induced pluripotent stem cells are the “functional equivalent” of human embryonic stem cells, a finding that may begin to settle a long running argument.
The findings were published this week in Nature Biotechnology.
Featuring CelBank advisor Dr. Joseph Purita
For a minimum price of $15,000, several professional athletes recently received a curious new medical treatment in New York.
It’s called “The Soup” — a mixture of human cells that includes stem cells derived from a patient’s own fat. If it works the way they hope, The Soup can help repair injuries that otherwise might require surgery — damaged knees, elbows, hips, necks and more.